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10:40
YouTube
Healthpodologenics2
The CRITICAL role of TSC2 on the Lysosomes
**TSC2 at the lysosome acts as a key brake on mTORC1 signaling.** Together with TSC1, TSC2 forms the TSC complex, which localizes to the lysosomal surface under low-nutrient or stress conditions. At the lysosome, TSC2 functions as a GAP for Rheb, converting Rheb-GTP to inactive Rheb-GDP, thereby suppressing mTORC1 activity. When nutrients and ...
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