Although the basic biochemistry of creatine is reviewed elsewhere in this issue (CITE), we will highlight a few facts that are pertinent to its possible role in the treatment of depression. Creatine is an organic acid that is synthesized from the amino acids arginine, glycine, and methionine.

The described methodological challenges obscure the relationship between brain creatine and the pathogenesis of psychiatric disorders. In summary, these issues highlight the need for caution when interpreting the positive findings for creatine in …

5 days ago · Creatine Could Ease Symptoms Of Depression, New Research Finds One psychologist calls the news “exciting.” By Korin Miller Published: Feb 05, 2025 2:24 PM EST

Feb 3, 2020 · Study results indicate a significant negative relationship between dietary creatine and depression in a nationally representative adult cohort. Further research is warranted to investigate the...

Feb 3, 2025 · Individuals considering creatine for depression should consult with healthcare professionals to ensure it's appropriate for their specific circumstances. In summary, creatine, commonly known for ...

Creatine supplementation reduces depressive symptoms, particularly when combined with selective serotonin reuptake inhibitors, and may improve brain energy metabolism and neuroplasticity.

Sep 7, 2023 · Although the current body of research suggests that creatine supplementation may offer a novel therapeutic approach for depression, especially in treatment-resistant cases, further randomized, placebo-controlled trials are warranted.

Aug 23, 2019 · Creatine, a widely available nutritional supplement, has the potential to improve these disruptions in some patients, and early clinical trials indicate that it may have efficacy as an antidepressant agent.