Introduction: Different oral sustained-release (SR) formulations of tramadol have been introduced in pain treatment in order to prolong the dosage interval to improve convenience for the patient. The ...

Twenty-four healthy subjects (12 male and 12 female) were included in the trial. They were aged between 22 and 45 (mean 34.4) years, and had body mass indexes of 19.0-28.8 (mean 24.7) kg/m 2. Major ...