An experimental opioid alternative called DFNZ achieved effective pain relief in mice without addiction risk or breathing ...

A novel mu-opioid receptor agonist showed strong analgesia without respiratory depression, tolerance, or significant ...

Scientists have developed a new gene therapy that quiets pain at its source in the brain—without the addictive risks of opioids. Using AI to map how pain is processed, they created a targeted “off ...

Researchers are investigating whether GLP-1 drugs could be used to treat addiction disorders, following patient reports of reduced cravings.

Buprenorphine saved Eric Ezzi. Heroin had overrun the Philadelphia-area native’s life in his early 20s. He lost jobs, went to jail and burned bridges with his family. A few years into his addiction, ...

Foundations Recovery Network, one of the nation’s leading organizations for treating a dual diagnosis of substance addiction and mental health disorders, recently put together an infographic on the ...

A large study of data from Veterans Affairs finds that people on GLP-1 drugs were less likely to develop substance abuse disorder or overdose.

As with other drugs, hydrocodone can cause side effects, such as constipation and nausea. If side effects of hydrocodone become difficult to tolerate, talk with your doctor or pharmacist. Hydrocodone ...

As drugs like Wegovy and Ozempic have become popular weight loss tools, some doctors and patients are also seeing a surprising side effect: diminished cravings for alcohol. Megan Johnston started ...

Some say kratom is as addictive as heroin; others say it's the cure to their chronic pain. The supplement is easily accessible across the country. To find out how individuals in the metro have been ...

Researchers have developed a compound that relieves pain in mice but doesn't affect the brain, thereby avoiding mind-altering side effects and abuse potential. The custom-designed molecule, derived ...