It is normal -- in fact necessary -- for our immune system to occasionally fly into an inflammatory rage to defend the host (us) against pathogens or even tumor cells. Problems arise when the rage ...
The body needs regulatory T cells (Tregs) on the sidelines of an immune attack, making sure tempers don’t run too hot and preventing the body’s lymphocytes from taking the body’s own cells. Because of ...
I’ve always enjoyed digital pinball on a variety of systems. Particularly the recreation of physical machines in digital form as these tables had months and months of development and design time ...
The alternative text for this image may have been generated using AI. Figure 3: SHARPIN-deficient T reg cells fail to retain their suppressive activity and Foxp3 expression. The alternative text for ...
La Jolla, Calif., December 11, 2017 - Researchers at Sanford Burnham Prebys Medical Discovery (SBP) and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one ...
Pinball machines – even virtual ones – can cost thousands. But pinball on a tablet or computer lacks the physicality of the real thing. Sharpin (from €149) aims to plug the gap. This virtual pinball ...
Integrins are heterodimeric transmembrane proteins composed of α- and β-subunits, which mediate cell–cell and cell–extracellular matrix adhesions 1. The affinity of integrins for their ligands ...
Mouse studies show protein mutations lead to chronic proliferative dermatitis. Two papers in Nature describe the role of the protein Sharpin (SHANK-associated RH domain interacting protein) in the ...
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