IN 1962, when David R. Davies was in his 30s, he and two coworkers at the National Institutes of Health proposed that short, guanine-rich stretches of DNA could assume unusual structures. On the basis ...

DNA G-quadruplexes (G4s) are a type of quadruple helix structure formed by a continuous guanine-rich DNA sequence. Although DNA G4s are thought to be involved in various biological processes, in many ...

Linear chromosome ends are capped with nucleoprotein complexes known as telomeres in order to avoid being recognized and processed as double-strand breaks (DSBs). Loss of capping, caused by telomere ...

DNA, the genetic material compacted in chromosomes, stores information to regulate all the cell processes in the body. Two decades ago, in addition to the widely known Watson-Crick double helix model ...

While two-dimensional modeling of double-stranded DNA molecules has been useful for the purpose of cancer research, the composition of the G-quadruplex, a four-stranded DNA sequence, has proven a ...

In 1953, Cambridge researchers Watson and Crick published an article describing the interweaving "double helix" DNA structure -- the chemical code for all life. Now, in the year of that scientific ...

There is no more iconic image in biology than that of DNA's double-stranded helix, which coils and supercoils on itself to form dense chromosomes. But a quite different, square-shaped type of DNA ...

Comparing the impact of nivolumab & ipilimumab combination therapy vs. dabrafenib & trametinib on outcomes in malignant melanoma patients: A global propensity-matched retrospective cohort study. This ...

Friederike Mansfeld does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations ...

Most women with ovarian cancer respond very well to chemotherapy at first – but in 70% of cases the cancer grows back. And although many patients will respond to chemotherapy a second or third time, ...