The kinase domain—the Pac-Man —is the catalytic center where the protein does its main job: adding a phosphate group to its target to control its activity. It has two subdomains—one small and one ...

After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structure of protein kinase C beta ...

After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structures of protein kinase C beta ...

A four-decade effort uncovered the molecular structure of PKCβ, revealing how the protein is activated and how the breast ...

Taste, pain, or response to stress -- nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers have uncovered the ...

A research team has identified a molecular mechanism that coordinates the operation of the N-methyl-D-aspartate (NMDA) glutamate receptor, which is key to regulating excitatory synapse function in the ...

Baylor College of Medicine has synthesized activin receptor type-1 (ACVR1; ALK2; ACTR-I) and/or serine/threonine-protein kinase receptor R3 (ACVRL1; ALK1) inhibitors reported to be useful for the ...

Researchers at ETH Zurich have identified a compound that blocks the aggregation of GRK2, a kinase protein whose clumping inside neurons drives mitochondrial damage and accelerates cell death in ...

Researchers created a DIA-MS atlas of 13,609 proteins across 2,856 samples from fetal, healthy adult, paired non-tumor, and ...

Researchers from the Biosciences Department at Durham University have discovered a previously unknown mechanism that helps plants control the formation of wood, a finding that could open new ...