The function of a protein is usually determined by the ligands that it binds to. The 3D structure of the binding groove or pocket can be compared to other proteins and similar residues used to make ...

'Inheritance through homology' is the most common and generally more accessible approach to function prediction, but orthology should be established where possible to improve confidence in predictions ...

In a recent study published in the journal Nature Machine Intelligence, researchers developed "DeepGO-SE," a method to predict gene ontology (GO) functions from protein sequences using a large, ...