If the cell nucleus is like a bank for DNA, nuclear pores are the security doors around its perimeter. Yet more security doors aren't necessarily better: some cancer cells contain a dramatic excess of ...

Researchers at Kanazawa University report in Cell Reports how alterations in the nuclear pores lead to the degradation of anti-tumor proteins. Several types of cancer are believed to be linked to ...

Scientists at Queen Mary University of London have discovered that HIV-1 can infect resting T-cells by triggering molecular signals that temporarily unlock the nuclear pore complex. This overturns ...

When it comes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and certain forms of dementia, researchers have known that protein quality control and damage to the nuclear ...

Nuclear pore complexes are more dynamic than previously thought, reshaping our understanding of a vital transport process in cells. An international study led by the University of Basel (Switzerland) ...

Researchers from Queen Mary University of London have uncovered a previously unknown mechanism by which HIV-1 can infect ...

In situ model of the nuclear pore complex transport barrier: Tethered within the pore are highly dynamic protein threads termed FG Nups (green). Under physiological conditions, cargo-carrying ...

Each cell contains well-defined compartments, each of which has a specific function. The nuclear envelope, for example, is a highly regulated membrane barrier that separates the nucleus from the ...