The central image depicts currently used strategies for clinical targeting of TGF-β. Below are methods applicable from preclinical screening to clinical practice, including using humanized mouse ...

Innate immunity is a cornerstone of the body’s immediate defense against cancer, orchestrating the early recognition and response to tumor cells through key ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...

Microscopic images of cranial blood vessels show the growth of mulberry-shaped CCMs over a 21 day period in control mice (top two rows). This growth is prevented by treatment with the TIE2 inhibitor ...