In this review, the authors present recent findings that uncover a previously unappreciated nuclear signaling hub: the PIPn-p53 signalosome. This complex not only modulates AKT activation within the ...

This review illustrates how the nuclear phosphoinositide-p53 signalosome integrates lipid signaling and p53 function to regulate cancer cell motility. The figure contrasts the tumor-suppressive ...

Cell migration is a multistep process essential to various physiological functions, including immune cell movement and embryonic development, as well as pathological conditions like tumor metastasis.

A new study integrated mathematical modeling with advanced imaging to discover that the physical shape of the fruit fly egg chamber, combined with chemical signals, significantly influences how cells ...

Ikoma, Japan—Ever wondered how the different cells in our body communicate with each other to fulfill their different roles—be it cells repairing a tissue injury or immune cells moving towards an ...

An integrin mutation impairs skin T cell migration, enabling HPV proliferation that causes warts and lesions in a rare ...

Konstanz researchers identify an enzyme that plays a role in the migration of cells in our body—not only during normal tissue formation and wound healing, but also when tumor cells metastasize. This ...